Matthew Bogyo Selected Research

Papain

11/2021	Challenges for Targeting SARS-CoV-2 Proteases as a Therapeutic Strategy for COVID-19.
1/2011	Non-invasive imaging of cysteine cathepsin activity in solid tumors using a 64Cu-labeled activity-based probe.
8/2008	Trial of the cysteine cathepsin inhibitor JPM-OEt on early and advanced mammary cancer stages in the MMTV-PyMT-transgenic mouse model.
10/2007	Noninvasive optical imaging of cysteine protease activity using fluorescently quenched activity-based probes.
8/2007	Inhibition of cysteine cathepsin protease activity enhances chemotherapy regimens by decreasing tumor growth and invasiveness in a mouse model of multistage cancer.
5/2007	Design, synthesis, and evaluation of in vivo potency and selectivity of epoxysuccinyl-based inhibitors of papain-family cysteine proteases.

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Matthew Bogyo Research Topics

Disease

44	Neoplasms (Cancer) 01/2022 - 05/2004
18	Malaria 01/2019 - 12/2002
13	Infections 01/2022 - 02/2007
12	Inflammation (Inflammations) 01/2020 - 11/2011
10	Carcinogenesis 12/2017 - 05/2004
9	Neoplasm Metastasis (Metastasis) 12/2019 - 05/2006
6	Breast Neoplasms (Breast Cancer) 09/2020 - 05/2006
4	Carcinoma (Carcinomatosis) 01/2020 - 05/2004
4	Atherosclerosis 10/2016 - 02/2012
3	Skin Neoplasms (Skin Cancer) 01/2020 - 02/2017
3	Parasitic Diseases (Parasitic Disease) 01/2019 - 07/2004
3	Pathologic Processes 01/2018 - 01/2007
3	Disease Progression 10/2016 - 10/2012
3	Pain (Aches) 01/2016 - 11/2011
3	Rupture 05/2011 - 11/2006
2	Virus Diseases (Viral Diseases) 01/2020 - 12/2019
2	Alzheimer Disease (Alzheimer's Disease) 01/2020 - 09/2005
2	Colitis 01/2020 - 11/2011
2	Falciparum Malaria (Plasmodium falciparum Malaria) 01/2019 - 01/2017
2	Colonic Neoplasms (Colon Cancer) 01/2018 - 12/2016
2	Hematologic Neoplasms (Hematological Malignancy) 11/2017 - 01/2017
2	Clostridium Infections 12/2016 - 09/2015
2	Pancreatic Neoplasms (Pancreatic Cancer) 10/2016 - 01/2016
2	Chronic Pancreatitis 01/2016 - 10/2012
2	Atherosclerotic Plaque (Atheroma) 01/2016 - 08/2004
2	Pancreatitis 01/2016 - 10/2012
2	Neuroblastoma 05/2015 - 05/2009
2	Hyperplasia 12/2012 - 04/2012
2	Thyroid Neoplasms (Thyroid Cancer) 08/2011 - 08/2010
1	Tuberculosis (Tuberculoses) 01/2022
1	COVID-19 11/2021
1	Residual Neoplasm 09/2020
1	Frontotemporal Dementia (Semantic Dementia) 01/2020
1	Dysbiosis 01/2020
1	Hypertension (High Blood Pressure) 01/2020
1	Paralysis (Palsy) 01/2019
1	Toxoplasmosis 01/2019
1	Mucolipidoses (Sialidosis) 01/2018
1	Brain Neoplasms (Brain Tumor) 12/2017
1	Cardiomyopathies (Cardiomyopathy) 12/2017
1	Noninfiltrating Intraductal Carcinoma (DCIS) 12/2017
1	Multiple Myeloma 11/2017

Drug/Important Bio-Agent (IBA)

38	Peptide Hydrolases (Proteases)FDA Link 11/2021 - 12/2002
36	CathepsinsIBA 01/2022 - 05/2004
18	Cysteine (L-Cysteine)FDA Link 09/2020 - 05/2004
14	Cysteine Proteases (Cysteine Protease)IBA 01/2019 - 12/2002
13	Proteins (Proteins, Gene)FDA Link 12/2019 - 05/2004
10	EnzymesIBA 01/2022 - 06/2006
8	Cathepsin BIBA 12/2017 - 09/2005
6	PapainIBA 11/2021 - 05/2007
6	Biological ProductsIBA 01/2020 - 02/2012
6	Proteasome Endopeptidase Complex (Proteasome)IBA 01/2019 - 08/2014
6	Biomarkers (Surrogate Marker)IBA 01/2018 - 01/2011
5	Pharmaceutical PreparationsIBA 11/2021 - 07/2004
5	Antimalarials (Antimalarial Agents)IBA 12/2018 - 08/2010
4	Contrast MediaIBA 01/2022 - 01/2011
4	AminopeptidasesIBA 01/2019 - 01/2011
4	asparaginylendopeptidase (legumain)IBA 01/2016 - 02/2010
3	Anti-Bacterial Agents (Antibiotics)IBA 01/2022 - 09/2015
3	Indicators and Reagents (Reagents)IBA 11/2016 - 10/2013
3	Cathepsin LIBA 10/2014 - 07/2004
3	Hemoglobins (Hemoglobin)IBA 11/2013 - 11/2006
2	HydrolasesIBA 10/2021 - 10/2016
2	Fluorescent Dyes (Fluorescent Probes)IBA 01/2020 - 01/2020
2	ProgranulinsIBA 01/2020 - 01/2017
2	ebselenIBA 01/2020 - 12/2016
2	Molecular Probes (Molecular Probe)IBA 01/2019 - 12/2016
2	Metalloproteases (Metalloproteinases)IBA 01/2019 - 01/2018
2	Protease Inhibitors (Protease Inhibitor)IBA 12/2017 - 08/2011
2	Proteasome InhibitorsIBA 11/2017 - 02/2016
2	cathepsin SIBA 10/2016 - 11/2011
2	ElastinIBA 10/2016 - 08/2004
2	InflammasomesIBA 03/2016 - 09/2012
2	CeruletideIBA 01/2016 - 10/2012
2	Peptides (Polypeptides)IBA 10/2014 - 05/2007
2	CollagenIBA 10/2013 - 08/2008
2	JPM 565IBA 08/2008 - 08/2007
2	Cysteine Proteinase InhibitorsIBA 03/2008 - 02/2007
2	AntigensIBA 03/2008 - 05/2007
2	falcipainIBA 06/2006 - 12/2002
1	LipidsIBA 10/2021
1	Amino Acids FDA Link 10/2020
1	GranulinsIBA 01/2020
1	Neurotransmitter Agents (Neurotransmitter)IBA 01/2019
1	DipeptidesIBA 01/2019
1	CarbohydratesIBA 01/2018
1	EndopeptidasesIBA 01/2018
1	Matrix Metalloproteinases (MMPs)IBA 01/2018
1	ZincIBA 01/2018
1	TubulinIBA 12/2017
1	N- (3- propylcarbamoyloxirane- 2- carbonyl)- isoleucyl- prolineIBA 12/2017
1	Cystatin AIBA 12/2017
1	carfilzomibIBA 11/2017

Therapy/Procedure

9	Therapeutics 01/2019 - 08/2007
2	Mohs Surgery (Mohs' Micrographic Surgery) 01/2020 - 02/2017
2	Endoscopes 01/2018 - 12/2016
2	Drug Therapy (Chemotherapy) 05/2015 - 08/2007
1	Computer-Assisted Surgery (Image Guided Surgery) 09/2020
1	Segmental Mastectomy (Lumpectomy) 09/2020
1	Lasers (Laser) 01/2018